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CISDOC database

Document ID (ISN)106501
CIS number 07-650
ISSN - Serial title 0944-2502 - Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie
Year 2004
Convention or series no.
Author(s) Morfeld P.
Title Findings of epidemiological studies on health effects of long-term occupational exposure to dusts of titanium dioxide pigments
Original title Ergebnisse epidemiologischer Studien zur gesundheitlichen Auswirkung von Langzeitexpositionen gegenüber Stäuben aus pigmentärem Titandioxid [in German]
Bibliographic information July 2004, Vol.54, No.7, p.246-258. 40 ref.
Abstract Titanium dioxide pigment dust is considered to be a representative example of a workplace dust that causes little or no adverse health effects. This literature survey reviews epidemiological studies in order to examine the hypothesis, based on experiments on mice, that granular biopersistent dust is carcinogenic in cases of long-term exposure to concentrations within permissible limits. Based on several epidemiological studies, and after taking confounding factors into account, it was not possible to demonstrate an increased risk of lung cancer after exposure to titanium dioxide pigment dust within MAK values (1.5mg/m3 of respirable TiO2 and 4 mg/m3 of inhalable TiO2).
Descriptors (primary) lung cancer; titanium dioxide; long-term exposure; respirable dust
Descriptors (secondary) literature survey; threshold limit values; animal experiments; epidemiologic study; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Diseases of the respiratory system (except for pneumoconiosis & similar)