|Document ID (ISN)||106394|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Paulsson B., Larsen K.O., T÷rnqvist M.
||Hemoglobin adducts in the assessment of potential occupational exposure to acylamides - Three case studies
||Apr. 2006, Vol.32, No.2, p.154-159. 29 ref.
||Workers in three types of occupations with potential exposure to acrylamide were examined by measurement of acrylamide adducts in haemoglobin. The first case concerned workers transporting acrylamide-contaminated waste soil, where no exposure was detectable. The second case included workers handling a sealing product containing acrylamide and N-methylolacrylamide, where moderate exposure was detected and where the sealant was replaced as a precautionary measure. The third case concerned a worker with observed neurotoxic symptoms, working with a sealing product containing acrylamide. This worker had an extremely high acrylamide-adduct level (23 nmol/g globin). The acrylamide product was replaced, and the adduct level substantially decreased within a year. These studies illustrate the usefulness of in vivo dose measurement using haemoglobin adducts for occupational surveillance and as a basis for the health risk assessment of electrophilically-reactive compounds.
||determination in blood; acrylamide; exposure tests
||neurotoxic effects; case study; haemoglobin; job-exposure relation; sealants; substitution; symptoms
||D - Periodical articles
|Country / State or Province||Denmark; Sweden|
||Toxic and dangerous substances
|Broad subject area(s)