| Document ID (ISN) | 106394 |
| CIS number |
07-393 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
2006 |
| Convention or series no. |
|
| Author(s) |
Paulsson B., Larsen K.O., Törnqvist M. |
| Title |
Hemoglobin adducts in the assessment of potential occupational exposure to acylamides - Three case studies |
| Bibliographic information |
Apr. 2006, Vol.32, No.2, p.154-159. 29 ref. |
| Abstract |
Workers in three types of occupations with potential exposure to acrylamide were examined by measurement of acrylamide adducts in haemoglobin. The first case concerned workers transporting acrylamide-contaminated waste soil, where no exposure was detectable. The second case included workers handling a sealing product containing acrylamide and N-methylolacrylamide, where moderate exposure was detected and where the sealant was replaced as a precautionary measure. The third case concerned a worker with observed neurotoxic symptoms, working with a sealing product containing acrylamide. This worker had an extremely high acrylamide-adduct level (23 nmol/g globin). The acrylamide product was replaced, and the adduct level substantially decreased within a year. These studies illustrate the usefulness of in vivo dose measurement using haemoglobin adducts for occupational surveillance and as a basis for the health risk assessment of electrophilically-reactive compounds. |
| Descriptors (primary) |
determination in blood; acrylamide; exposure tests |
| Descriptors (secondary) |
neurotoxic effects; case study; haemoglobin; job-exposure relation; sealants; substitution; symptoms |
| Document type |
D - Periodical articles |
| Country / State or Province | Denmark; Sweden |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Amides
Biological monitoring
|
