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Document ID (ISN)106394
CIS number 07-393
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2006
Convention or series no.
Author(s) Paulsson B., Larsen K.O., T÷rnqvist M.
Title Hemoglobin adducts in the assessment of potential occupational exposure to acylamides - Three case studies
Bibliographic information Apr. 2006, Vol.32, No.2, p.154-159. 29 ref.
Abstract Workers in three types of occupations with potential exposure to acrylamide were examined by measurement of acrylamide adducts in haemoglobin. The first case concerned workers transporting acrylamide-contaminated waste soil, where no exposure was detectable. The second case included workers handling a sealing product containing acrylamide and N-methylolacrylamide, where moderate exposure was detected and where the sealant was replaced as a precautionary measure. The third case concerned a worker with observed neurotoxic symptoms, working with a sealing product containing acrylamide. This worker had an extremely high acrylamide-adduct level (23 nmol/g globin). The acrylamide product was replaced, and the adduct level substantially decreased within a year. These studies illustrate the usefulness of in vivo dose measurement using haemoglobin adducts for occupational surveillance and as a basis for the health risk assessment of electrophilically-reactive compounds.
Descriptors (primary) determination in blood; acrylamide; exposure tests
Descriptors (secondary) neurotoxic effects; case study; haemoglobin; job-exposure relation; sealants; substitution; symptoms
Document type D - Periodical articles
Country / State or ProvinceDenmark; Sweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Biological monitoring