| Document ID (ISN) | 106365 |
| CIS number |
07-387 |
| ISSN - Serial title |
0105-1873 - Contact Dermatitis |
| Year |
2006 |
| Convention or series no. |
|
| Author(s) |
Thyssen J.P., Sederberg-Olsen N., Thomsen J.F., Menné T. |
| Title |
Contact dermatitis from methylisothiazolinone in a paint factory |
| Bibliographic information |
June 2006, Vol.54, No.6, p.322-324. 16 ref. |
| Abstract |
The introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methyl-isothiazolinone (MI) and not methyl-chloroisothiazolinone (MCI) has recently been introduced for use in products such as paint, glue and cosmetics. This article describes an outbreak of contact allergy to MI and MCI among four out of 14 workers in a paint factory. Patch test results from all four patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization may be seen in the future. The data show that MI holds a potential for eliciting and probably inducing contact allergy in humans. |
| Descriptors (primary) |
allergens; paint and varnish industry; skin diseases; biocides; isothiazolinones |
| Descriptors (secondary) |
2-methyl-2,3-dihydroisothiazol-3-one; case study; 5-chloro-2-methyl-2,3-dihydroisothiazol-3-one; sensitization; eczema; allergy tests; skin tests; cosmetics |
| Document type |
D - Periodical articles |
| Country / State or Province | Denmark |
| Subject(s) |
Chemicals, plastics and rubber
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Skin diseases
Heterocyclic compounds
|
