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CISDOC database

Document ID (ISN)106346
CIS number 07-319
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Zhu J.L., Knudsen L.E., Andersen A.M.N., Hjollund N.H., Olsen J.
Title Laboratory work and pregnancy outcomes: A study within the National Birth Cohort in Denmark
Bibliographic information Jan. 2006, Vol.63, No.1, p.53-58. 33 ref.
Abstract To examine pregnancy outcomes in women doing laboratory work, this prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference) used data from the Danish National Birth Cohort (1997-2003). Laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios of late foetal loss and diagnosis of congenital malformations were calculated by using Cox regression, and odds ratios of preterm birth and small for gestational age were calculated by using logistic regression. The overall results did not indicate any high risk of reproductive failures in laboratory technicians. However, risks of preterm birth and congenital malformations were observed among subgroups with high exposures to radioisotopes and organic solvents.
Descriptors (primary) antifertility effects; laboratory work; expectant mothers; women; complications of pregnancy
Descriptors (secondary) embryotoxic effects; Denmark; radioactive substances; teratogenic effects; abortion; cohort study; organic solvents
Document type D - Periodical articles
Country / State or ProvinceDenmark; USA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the reproductive system
Genetic factors in reaction to exposures
Antifertility and prenatal effects