|Document ID (ISN)||106285|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Lawton B.W., Hoffmann J., Triebig G.
||The ototoxicity of styrene: A review of occupational investigations
||Feb. 2006, Vol.79, No.2, p.93-102. Illus. 23 ref.
||Seven occupational studies dealing with the ototoxicity of styrene were analysed. Factors assessed included the experimental design, measurement of the styrene-in-air concentration, confirmation of styrene exposure by blood or urine analysis, determination of hearing threshold levels and measurement of noise at the workplace. Findings are equivocal. Four investigations failed to find any effect of styrene on hearing thresholds. In contrast, other investigations claimed to have demonstrated styrene-induced hearing loss in industrial populations, with synergism between styrene and noise. However, these reports exhibited shortcomings of experimental design and data analysis. Considering the body of evidence as a whole, hearing deficits due to occupational exposure to styrene at low concentrations have not been demonstrated by scientifically reliable argument.
||styrene; ototoxic effects; hearing loss
||literature survey; exposure evaluation; epidemiologic study; determination in urine; synergism; determination in blood; hearing threshold
||D - Periodical articles
|Country / State or Province||Germany; United Kingdom|
||Toxic and dangerous substances
|Broad subject area(s)
Diseases of the ear and hearing damage