ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)106279
CIS number 07-369
ISSN - Serial title 1232-1087 - International Journal of Occupational Medicine and Environmental Health
Year 2006
Convention or series no.
Author(s) Pakulska D., Czerczak S.
Title Hazardous effects of arsine: A short review
Bibliographic information 1st quarter 2006, Vol.19, No.1, p.36-44. 51 ref.
Abstract This article reviews the mechanisms by which arsine exerts its toxic effects and examines conditions of occupational exposure to this gas. Occupational exposure to arsine occurs mostly in the chemical and metallurgical industries. In these industries, arsine is often a cause of unexpected serious poisoning, affecting primarily the blood and kidneys. Acute arsine poisoning results in massive damage to red blood cells through an oxidative mechanism, probably by formation of hydrogen peroxide and adducts with oxyhaemoglobin. According to another hypothesis, arsine acts on the sodium-potassium pump mechanism, producing subsequent red blood cell swelling and haemolysis. Rapid haemolysis may lead to oliguric renal failure and death. Symptoms of chronic poisoning are similar to those observed in acute poisoning. The main difference is a longer latency period. Delayed effects of chronic exposure to low levels of arsine have not been precisely identified.
Descriptors (primary) arsine; health hazards; toxicology
Descriptors (secondary) osmotic pressure changes in blood; acute toxicity; acute poisoning; hydrogen peroxide; nephrotoxic effects; renal insufficiency; chronic toxicity; chronic poisoning; haemolysis
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Arsenic and compounds
Inorganic substances