|Document ID (ISN)||106279|
|ISSN - Serial title
||1232-1087 - International Journal of Occupational Medicine and Environmental Health
|Convention or series no.
||Pakulska D., Czerczak S.
||Hazardous effects of arsine: A short review
||1st quarter 2006, Vol.19, No.1, p.36-44. 51 ref.
||This article reviews the mechanisms by which arsine exerts its toxic effects and examines conditions of occupational exposure to this gas. Occupational exposure to arsine occurs mostly in the chemical and metallurgical industries. In these industries, arsine is often a cause of unexpected serious poisoning, affecting primarily the blood and kidneys. Acute arsine poisoning results in massive damage to red blood cells through an oxidative mechanism, probably by formation of hydrogen peroxide and adducts with oxyhaemoglobin. According to another hypothesis, arsine acts on the sodium-potassium pump mechanism, producing subsequent red blood cell swelling and haemolysis. Rapid haemolysis may lead to oliguric renal failure and death. Symptoms of chronic poisoning are similar to those observed in acute poisoning. The main difference is a longer latency period. Delayed effects of chronic exposure to low levels of arsine have not been precisely identified.
||arsine; health hazards; toxicology
||osmotic pressure changes in blood; acute toxicity; acute poisoning; hydrogen peroxide; nephrotoxic effects; renal insufficiency; chronic toxicity; chronic poisoning; haemolysis
||D - Periodical articles
|Country / State or Province||Poland|
||Toxic and dangerous substances
|Broad subject area(s)
||Arsenic and compounds