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Document ID (ISN)106090
CIS number 07-157
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) González-Yebra A.L., Kornhauser C., Wrobel K., Pérez-Luque E.L., Barbosa G.
Title Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers
Bibliographic information Mar. 2006, Vol.79, No.3, p.259-264. Illus. 27 ref.
Abstract Many shoe workers in Leon, Mexico, are in continuous contact with toluene-based glues. The objective of this case-control study involving 50 toluene-exposed shoe workers and 25 control subjects was to evaluate the relationship between toluenel exposure and renal damage. Urinary o-cresol excretion was used as a measure of toluene exposure. Urinary albumin excretion and N-acetyl-Β-D-glucosaminidase (NAG) enzymatic activity were tested to assess renal dysfunction. Urinary o-cresol levels were higher in exposed subjects. Albumin excretion was similar in the exposed and control groups. NAG enzymatic activity was greater in the exposed group compared to the control group (3.5 U/g vs 1.9 U/g creatinine). An inverse relationship was found between schooling years and the NAG enzymatic activity for the two studied groups. The findings support the hypothesis that toluene may be a factor associated with the presence of renal damage in exposed shoe workers.
Descriptors (primary) toluene; shoe industry; renal damage
Descriptors (secondary) Mexico; adhesives; determination in urine; case-control study; enzyme activity determination; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceMexico
Subject(s) Leather, fur and footwear
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Footwear, leather and fur industry
Diseases of the kidney and the urinary system
Aromatic hydrocarbons