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CISDOC database

Document ID (ISN)106071
CIS number 07-171
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Radican L., Wartenberg D., Rhoads G.G., Schneider D., Wedeen R., Stewart P., Blair A.
Title A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons
Bibliographic information Jan. 2006, Vol.48, No.1, p.1-12. 32 ref.
Abstract Various case-control studies suggest that hydrocarbons increase end-stage renal disease (ESRD) risk. No cohort studies have been conducted. In this study, an occupational database was matched to the U.S. Renal Data System, and the outcome of ESRDs was examined using multivariable Cox regression. Sixteen individual hydrocarbons were studied. For the 1973-2000 period there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene, 1,1,1-trichloroethane, and JP4 gasoline compared with unexposed subjects. Relative risk was greater than unity for several other hydrocarbons. Associations attenuated when 2001-2002 data were included in the analyses. It is concluded that certain hydrocarbons may increase ESRD risk, although some findings are contradictory and further research is needed.
Descriptors (primary) aromatic hydrocarbons; renal diseases; aliphatic hydrocarbons; aircraft; organic solvents
Descriptors (secondary) USA; cohort study; trichloroethylene; 1,1,1-trichloroethane
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Transport and communications
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Air transportation
Diseases of the kidney and the urinary system
Aromatic hydrocarbons
Aliphatic and alicyclic hydrocarbons