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Document ID (ISN)105879
CIS number 06-1264
Year 2005
Convention or series no. ECETOC JACC No.49
Author(s) Gribble M.
Title Vinylidene fluoride (CAS No. 75-38-7)
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Nov. 2005. 54p. Illus. 81 ref.
Abstract Conclusions of this criteria document on vinylidene fluoride (VDF): VDF has low acute and chronic toxicity in laboratory animals. It is not genotoxic either in vitro or in vivo. Although rats developed carcinomas in a one-year oral study, subsequent lifetime inhalation studies in rats and mice showed no adverse effects at high doses. It is therefore unlikely that VDF has significant long-term toxic or carcinogenic properties. VDF has no effects on rat fertility or reproduction. A teratology study did not indicate any embryotoxic, foetotoxic or teratogenic effects at high concentrations. There are no data on the effects of human exposure. The ACGIH has established a threshold limit value of 500ppm or 1300mg/m3.
Descriptors (primary) 1,1-difluoroethylene; toxicology
Descriptors (secondary) threshold limit values; acute toxicity; criteria document; chronic toxicity; animal experiments
Document type B - Chemical safety information sheets
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons