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Document ID (ISN)105844
CIS number 06-1341
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2005
Convention or series no.
Author(s) Chia S.E., Zhou H.J., Yap E., Tham M.T., Dong N.V., Hong Tu N.T., Chia K.S.
Title Association of renal function and δ-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead
Bibliographic information 2006, Vol. 63, p.180-186. Illus. 23 ref.
Abstract The effect of δ-aminolevulinic acid dehydratase (ALAD) polymorphisms on the association between blood lead and renal function was investigated among Vietnamese and Singaporean workers exposed to low to medium levels of inorganic lead. The distribution of ALAD polymorphism among Vietnamese, Chinese, Malays and Indians was also studied. Blood and urine samples were analysed for blood lead, ALAD genotype, urinary δ-aminolevulinic acid and renal function. ALAD1-1 was the predominant genotype for all ethnic groups while ALAD2-2 was the rarest. Results indicated that workers with the ALAD2 allele appeared to be more susceptible to the effects of lead (especially at higher levels) on renal function.
Descriptors (primary) lead; individual susceptibility; renal function tests; renal diseases
Descriptors (secondary) Singapore; determination in urine; determination in blood; Viet Nam
Document type D - Periodical articles
Country / State or ProvinceSingapore; Viet Nam
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Inorganic substances
Diseases of the kidney and the urinary system
Lead and compounds