|Document ID (ISN)||105767|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Maroni M., Fanetti A.C.
||Liver function assessment in workers exposed to vinyl chloride
||Jan. 2006, Vol.79, No.1, p.57-65. 17 ref.
||http://www.springerlink.com/content/j110530u28817775/fulltext.pdf [in English]
||A medical examination including liver function tests (LFTs) and liver ultrasonography was carried out in a group of 757 workers with long-standing service in the production of vinyl chloride monomer (VCM) and polyvinyl chloride (PVC) in four production plants in Italy. Cumulative and maximum VCM exposures were calculated. Possible histories of viral hepatitis and alcohol intake habits of subjects were carefully investigated. Regression analysis explored the association between abnormal LFTs and a group of possible determinants. Results indicate that liver function assessment only (including LFTs) is not able to detect VCM-induced liver damage, but reveals alterations due to non-occupational factors, such as dietary and/or metabolic dysfunctions. The LFTs are however of importance in detecting conditions that indicate the need to avoid VCM exposure.
||chemical industry; hepatic damage; liver function tests; polyvinyl chloride; vinyl chloride
||hepatotoxic effects; Italy; alcoholism; ultrasonic examinations; liver cancer; exposure evaluation; long-term exposure; infectious hepatitis
||D - Periodical articles
|Country / State or Province||Italy|
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
Viral diseases (other than aids)
Alcohol and drug abuse
Bacterial and parasitic diseases