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Document ID (ISN)105767
CIS number 06-1400
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Maroni M., Fanetti A.C.
Title Liver function assessment in workers exposed to vinyl chloride
Bibliographic information Jan. 2006, Vol.79, No.1, p.57-65. 17 ref.
Internet access http://www.springerlink.com/content/j110530u28817775/fulltext.pdf [in English]
Abstract A medical examination including liver function tests (LFTs) and liver ultrasonography was carried out in a group of 757 workers with long-standing service in the production of vinyl chloride monomer (VCM) and polyvinyl chloride (PVC) in four production plants in Italy. Cumulative and maximum VCM exposures were calculated. Possible histories of viral hepatitis and alcohol intake habits of subjects were carefully investigated. Regression analysis explored the association between abnormal LFTs and a group of possible determinants. Results indicate that liver function assessment only (including LFTs) is not able to detect VCM-induced liver damage, but reveals alterations due to non-occupational factors, such as dietary and/or metabolic dysfunctions. The LFTs are however of importance in detecting conditions that indicate the need to avoid VCM exposure.
Descriptors (primary) chemical industry; hepatic damage; liver function tests; polyvinyl chloride; vinyl chloride
Descriptors (secondary) hepatotoxic effects; Italy; alcoholism; ultrasonic examinations; liver cancer; exposure evaluation; long-term exposure; infectious hepatitis
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Liver diseases
Viral diseases (other than aids)
Halogenated hydrocarbons
Alcohol and drug abuse
Chemical industry
Bacterial and parasitic diseases