|Document ID (ISN)||105510|
|Convention or series no.
||National Industrial Chemicals Notification and Assessment Scheme (NICNAS), GPO Box 58, Sydney NSW 2001, Australia, 2003. 5p. 7 ref.
||http://www.nicnas.gov.au/Publications/Information_Sheets/Existing_Chemical_Information_Sheets/ECIS_urea_PDF.pdf [in English]
||Existing Chemicals Information Sheet. There are no data suggesting that urea is a skin sensitizer, a carcinogen or a reproductive toxicant. Urea has not been rigorously examined with respect to reproductive and developmental toxitity. However, chronic toxicity and carcinogenicity studies have suggested a no observed adverse effect level of 2000-6000mg/kg bw/day in rats and mice. Though it does appear to have genotoxic properties, this occurs at doses far in excess of what a person would normally expect to be exposed to. The toxicity of urea appears to be restricted to skin irritation, which was reported in a single human study. The risk to humans from urea depends on the level of exposure to the chemical. The bulk of human exposure to urea comes from food, and occupational exposure adds little to the amount received orally. Despite the human health effects associated with urea together with data indicating potentially extensive use in both industrial and consumer areas, it appears that for both consumers and workers the human health hazards are low.
||data sheet; irritants
||B - Chemical safety information sheets
|Country / State or Province||Australia|
||Toxic and dangerous substances
|Broad subject area(s)