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CISDOC database

Document ID (ISN)105510
CIS number 06-1010
Year 2003
Convention or series no.
Title Urea
Bibliographic information National Industrial Chemicals Notification and Assessment Scheme (NICNAS), GPO Box 58, Sydney NSW 2001, Australia, 2003. 5p. 7 ref.
Internet access http://www.nicnas.gov.au/Publications/Information_Sheets/Existing_Chemical_Information_Sheets/ECIS_urea_PDF.pdf [in English]
Abstract Existing Chemicals Information Sheet. There are no data suggesting that urea is a skin sensitizer, a carcinogen or a reproductive toxicant. Urea has not been rigorously examined with respect to reproductive and developmental toxitity. However, chronic toxicity and carcinogenicity studies have suggested a no observed adverse effect level of 2000-6000mg/kg bw/day in rats and mice. Though it does appear to have genotoxic properties, this occurs at doses far in excess of what a person would normally expect to be exposed to. The toxicity of urea appears to be restricted to skin irritation, which was reported in a single human study. The risk to humans from urea depends on the level of exposure to the chemical. The bulk of human exposure to urea comes from food, and occupational exposure adds little to the amount received orally. Despite the human health effects associated with urea together with data indicating potentially extensive use in both industrial and consumer areas, it appears that for both consumers and workers the human health hazards are low.
Descriptors (primary) urea; Australia
Descriptors (secondary) data sheet; irritants
Document type B - Chemical safety information sheets
Country / State or ProvinceAustralia
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides