|Document ID (ISN)||105440|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Lacasse Y., Martin S., Simard S., Desmeules M.
||Meta-analysis of silicosis and lung cancer
||Dec. 2005, Vol.31, No.6, p.450-458. Illus. 66 ref.
||This study examined the association between silicosis and lung cancer in 31 studies (27 cohort studies and four case-control studies) that reported a measure of association (standardized mortality ratio, relative risk or odds ratio) relating lung cancer to silicosis. Without adjustment for smoking, the analysis indicated that the common standardized mortality ratio (SMR) was 2.45. When the results of the cohorts for which mortality data were adjusted for smoking were pooled, the common SMR was 1.60. In a dose-response analysis, the profusion of small and large opacities found in chest X-rays correlated with the risk of death from lung cancer. Because of biases inherent to observational studies, it is likely that the risk of lung cancer among silicosis patients is overestimated in current literature. There is nevertheless evidence that silicosis and lung cancer are associated.
||epidemiological aspects; silicosis; lung cancer
||literature survey; smoking; opacities; confounding factors; statistical evaluation; mortality
||D - Periodical articles
|Country / State or Province||Canada|
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
Diseases of the respiratory system (except for pneumoconiosis & similar)