|Document ID (ISN)||105193|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Yokota K., Ikeda N., Johyama Y., Michitsuji H., Yamada S.
||Urinary methoxyacetic acid as an indicator of occupational exposure to ethylene glycol dimethyl ether
||Sep. 2005, Vol.78, No.8, p.650-654. Illus. 16 ref.
||http://www.springerlink.com/media/99eqahwvmk4xnchyyjvw/contributions/q/2/m/7/q2m7433340082310.pdf [in English]
||This case-control study investigated the use of urinary methoxyacetic acid (MAA) as a biomarker for exposure to ethylene glycol dimethyl ether (EGdiME). Urine samples were collected from 14 exposed and 20 unexposed subjects. The identification and quantification of the metabolite were performed using gas chromatography coupled with mass spectrometry and flame ionisation detection. Air samples were also collected. The levels of urinary MAA among exposed workers were significantly higher than among controls, showing a clear exposure-response relationship. These findings confirm that MAA in urine may be used for biological monitoring of EGdiME exposures.
||1,2-dimethoxyethane; determination in urine; exposure tests; methoxyacetic acid
||exposure evaluation; case-control study; urinary metabolites; description of technique; sampling and analysis; determination in air; dose-response relationship
||D - Periodical articles
|Country / State or Province||Japan|
||Toxic and dangerous substances
|Broad subject area(s)