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Document ID (ISN)105193
CIS number 06-662
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2005
Convention or series no.
Author(s) Yokota K., Ikeda N., Johyama Y., Michitsuji H., Yamada S.
Title Urinary methoxyacetic acid as an indicator of occupational exposure to ethylene glycol dimethyl ether
Bibliographic information Sep. 2005, Vol.78, No.8, p.650-654. Illus. 16 ref.
Internet access http://www.springerlink.com/media/99eqahwvmk4xnchyyjvw/contributions/q/2/m/7/q2m7433340082310.pdf [in English]
Abstract This case-control study investigated the use of urinary methoxyacetic acid (MAA) as a biomarker for exposure to ethylene glycol dimethyl ether (EGdiME). Urine samples were collected from 14 exposed and 20 unexposed subjects. The identification and quantification of the metabolite were performed using gas chromatography coupled with mass spectrometry and flame ionisation detection. Air samples were also collected. The levels of urinary MAA among exposed workers were significantly higher than among controls, showing a clear exposure-response relationship. These findings confirm that MAA in urine may be used for biological monitoring of EGdiME exposures.
Descriptors (primary) 1,2-dimethoxyethane; determination in urine; exposure tests; methoxyacetic acid
Descriptors (secondary) exposure evaluation; case-control study; urinary metabolites; description of technique; sampling and analysis; determination in air; dose-response relationship
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Glycol ethers
Biological monitoring