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Document ID (ISN)105191
CIS number 06-661
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2005
Convention or series no.
Author(s) Tomenson J.A., Carpenter A.V., Pemberton M.A.
Title Critical review of the epidemiology literature on the potential cancer risks of methyl methacrylate
Bibliographic information Sep. 2005, Vol.78, No.8, p.603-612. 15 ref.
Internet access [in English]
Abstract This literature review on the carcinogenicity of methyl methacrylate (MMA) to humans focused on cast acrylic sheet manufacturing workers because of the high exposure potential in this industry. Excesses of respiratory, stomach and colorectal cancers were observed in some cohorts of workers exposed to MMA, although there was little to suggest that MMA exposure was responsible for these excesses of respiratory and stomach cancer and it is more likely that they resulted from lifestyle exposures such as cigarette smoking or diet. An excess of colorectal cancer in one group of workers exposed to high levels of MMA during the 1930s and 1940s remains unexplained. Overall, the lack of consistency of the various studies, the absence of dose-response relationships and the lack of support from animal toxicology do not provide persuasive evidence that MMA is a human carcinogen.
Descriptors (primary) polyacrylates; plastics converting industry; cancer; methyl methacrylate
Descriptors (secondary) literature survey; carcinogens; rectal cancer; smoking; cohort study; lung cancer; gastrointestinal cancer; confounding factors; diet
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Acrylates