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Document ID (ISN)105103
CIS number 06-645
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2005
Convention or series no.
Author(s) Graf J.J., Sathiakumar N., Macaluso M., Maldonado G., Matthews R., Delzell E.
Title Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality
Bibliographic information Sep. 2005, Vol.47, No.9, p.916-932. 50 ref.
Abstract This study evaluated the association between exposure to several chemicals and mortality from lymphohaematopoietic cancer (LHC) among 16,579 synthetic rubber industry workers who were followed up from 1943 to 1998. Poisson regression analyses examined LHC rates in relation to butadiene, styrene and dimethyl dithiocarbamate (DMDTC) exposure, after adjusting for other agents and potential confounders. Cumulative exposure to 1,3-butadiene was associated positively with all leukaemia, chronic myelogenous leukaemia and to a lesser extent with chronic lymphocytic leukaemia. Adjusting for styrene and DMDTC attenuated these associations. After controlling for butadiene, neither styrene nor DMDTC displayed a consistent exposure-response trend, whether for all leukaemia, chronic myelogenous leukaemia, or chronic lymphocytic leukaemia.
Descriptors (primary) cancer; leukaemia; synthetic rubber industry
Descriptors (secondary) butadiene; styrene; dithiocarbamates; mortality; bone marrow diseases; myelogenous leukaemia; lymphatic leukaemia; exposure evaluation; long-term study; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Leukaemia
Plastics industry
Chemical industry