|Document ID (ISN)||105103|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Graf J.J., Sathiakumar N., Macaluso M., Maldonado G., Matthews R., Delzell E.
||Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality
||Sep. 2005, Vol.47, No.9, p.916-932. 50 ref.
||This study evaluated the association between exposure to several chemicals and mortality from lymphohaematopoietic cancer (LHC) among 16,579 synthetic rubber industry workers who were followed up from 1943 to 1998. Poisson regression analyses examined LHC rates in relation to butadiene, styrene and dimethyl dithiocarbamate (DMDTC) exposure, after adjusting for other agents and potential confounders. Cumulative exposure to 1,3-butadiene was associated positively with all leukaemia, chronic myelogenous leukaemia and to a lesser extent with chronic lymphocytic leukaemia. Adjusting for styrene and DMDTC attenuated these associations. After controlling for butadiene, neither styrene nor DMDTC displayed a consistent exposure-response trend, whether for all leukaemia, chronic myelogenous leukaemia, or chronic lymphocytic leukaemia.
||cancer; leukaemia; synthetic rubber industry
||butadiene; styrene; dithiocarbamates; mortality; bone marrow diseases; myelogenous leukaemia; lymphatic leukaemia; exposure evaluation; long-term study; cohort study
||D - Periodical articles
|Country / State or Province||USA|
||Chemicals, plastics and rubber
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology