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Document ID (ISN)105048
CIS number 06-625
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2005
Convention or series no.
Author(s) Laffon B., Teixeira J.P., Silva S., Loureiro J., Torres J., Pásaro E., Méndez J., Mayan O.
Title Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes
Bibliographic information Aug. 2005, Vol.48, No.2, p.128-136. Illus. 75 ref.
Abstract Concern about the genotoxic risk associated with chronic handling of antineoplastic drugs has increased, and usual safety practices may not avoid exposure. The comet assay and micronuclei (MN) test were performed on 30 oncology nurses and 22 controls. Data obtained showed increased cytogenetic and DNA damage in the exposed group, although statistical significance was only reached in the comet assay. There is evidence that the present handling practices of antineoplastic drugs in some Portuguese hospitals may not prevent exposure. Present data suggest that genetic polymorphisms in the studied DNA repair enzymes may influence the individual susceptibility to DNA damage related to chronic handling of antineoplastic drugs.
Descriptors (primary) antineoplastic drugs; Portugal; chromosome changes; health care personnel; genetic effects; hospitals
Descriptors (secondary) DNA; individual susceptibility; case-control study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceSpain; Portugal
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures