|Document ID (ISN)||105048|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Laffon B., Teixeira J.P., Silva S., Loureiro J., Torres J., Pásaro E., Méndez J., Mayan O.
||Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes
||Aug. 2005, Vol.48, No.2, p.128-136. Illus. 75 ref.
||Concern about the genotoxic risk associated with chronic handling of antineoplastic drugs has increased, and usual safety practices may not avoid exposure. The comet assay and micronuclei (MN) test were performed on 30 oncology nurses and 22 controls. Data obtained showed increased cytogenetic and DNA damage in the exposed group, although statistical significance was only reached in the comet assay. There is evidence that the present handling practices of antineoplastic drugs in some Portuguese hospitals may not prevent exposure. Present data suggest that genetic polymorphisms in the studied DNA repair enzymes may influence the individual susceptibility to DNA damage related to chronic handling of antineoplastic drugs.
||antineoplastic drugs; Portugal; chromosome changes; health care personnel; genetic effects; hospitals
||DNA; individual susceptibility; case-control study; exposure evaluation
||D - Periodical articles
|Country / State or Province||Spain; Portugal|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures