|Document ID (ISN)||105018|
|ISSN - Serial title
||0105-1873 - Contact Dermatitis
|Convention or series no.
||Cavallo D., Ursini C.L., Setini A., Chianese C., Cristaudo A., Iavicoli S.
||DNA damage and TNFα cytokine production in hairdressers with contact dermatitis
||Sep. 2005, Vol.53, No.3, p.125-129. 17 ref.
||This study examined the possible correlation between exposure of hairdressers to irritants and allergens and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. The evaluation involved 19 hairdressers with hand contact dermatitis, including 14 with allergic contact dermatitis (ACD) and five with irritant contact dermatitis (ICD), together with a control group of 19 persons working in administrative services. Determinations included TNFα serum levels and a direct-oxidative DNA damage test. Serum levels of TNFα in hairdressers with ACD were significantly higher than controls, with a correlation to exposure level. Significantly more DNA damage in ICD hairdressers with higher exposure was found as compared to controls. These findings suggest a relationship between exposure and direct-oxidative DNA damage, TNFα production and allergic inflammatory disease.
||DNA; allergies; hairdressing; inflammations; eczema
||allergens; irritants; Italy; case-control study; hand; exposure evaluation; skin diseases
||D - Periodical articles
|Country / State or Province||Italy|
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
Hairdressing & beauty parlours