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CISDOC database

Document ID (ISN)105018
CIS number 06-619
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2005
Convention or series no.
Author(s) Cavallo D., Ursini C.L., Setini A., Chianese C., Cristaudo A., Iavicoli S.
Title DNA damage and TNFα cytokine production in hairdressers with contact dermatitis
Bibliographic information Sep. 2005, Vol.53, No.3, p.125-129. 17 ref.
Abstract This study examined the possible correlation between exposure of hairdressers to irritants and allergens and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. The evaluation involved 19 hairdressers with hand contact dermatitis, including 14 with allergic contact dermatitis (ACD) and five with irritant contact dermatitis (ICD), together with a control group of 19 persons working in administrative services. Determinations included TNFα serum levels and a direct-oxidative DNA damage test. Serum levels of TNFα in hairdressers with ACD were significantly higher than controls, with a correlation to exposure level. Significantly more DNA damage in ICD hairdressers with higher exposure was found as compared to controls. These findings suggest a relationship between exposure and direct-oxidative DNA damage, TNFα production and allergic inflammatory disease.
Descriptors (primary) DNA; allergies; hairdressing; inflammations; eczema
Descriptors (secondary) allergens; irritants; Italy; case-control study; hand; exposure evaluation; skin diseases
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Skin diseases
Hairdressing & beauty parlours
Allergies