|Document ID (ISN)||105012|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Sakai T., Morita Y., Roh J., Kim H., Kim Y.
||Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate
||July 2005, Vol.78, No.6, p.459-466. Illus. 22 ref.
||The objective of this study was to develop a simple and sensitive gas chromatography-mass spectrometry (GC-MS) method for determining toluene-diamine (TDA) in urine and to apply the method for biological monitoring of workers exposed to toluene-diisocyanate (TDI). The method involved acid hydrolysis urine followed by the extraction of the free TDA with dichloromethane and the determination of the heptafluorobutyric anhydride derivative by GC-MS. This method was applied to the biological monitoring of 18 workers exposed to an 80:20 mixture of 2,4-TDI and 2,6-TDI. The method was found to be simple and practicable, showing a good correlation with personal TDI exposures.
||tolylene diisocyanate; determination in urine; exposure tests
||mass spectrometry; 2,6-tolylene diisocyanate; gas chromatography; exposure evaluation; description of technique; 2,4-tolylene diisocyanate
||D - Periodical articles
|Country / State or Province||Japan; Korea, Republic of|
||Toxic and dangerous substances
|Broad subject area(s)