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CISDOC database

Document ID (ISN)105007
CIS number 06-612
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2005
Convention or series no.
Author(s) Sennbro C.J., Littorin M., Tinnerberg H., J÷nsson B.A.G.
Title Upper reference limits for biomarkers of exposure to aromatic diisocyanates
Bibliographic information Aug. 2005, Vol.78, No.7, p.541-546. Illus. 28 ref.
Abstract The objectives of this study were to determine the levels of biomarkers of exposure to several diisocyanates in the urine and blood of occupationally unexposed workers and to calculate their upper reference limits (URLs). Biomarker levels were determined in urinary and plasma samples obtained from 121 occupationally unexposed workers. URLs were then calculated based on these biomarker levels and the levels in an occupationally exposed group of workers. These URLs may be used for screening for occupational exposure, a worker with a biomarker level above the URL being classified as occupationally exposed. Biomarkers of aromatic diisocyanates, especially biomarkers of 4,4'-methylenediphenyl diisocyanate, were present among occupationally unexposed workers, but the source and nature of the exposure is unknown.
Descriptors (primary) exposure tests; isocyanates
Descriptors (secondary) diphenylmethane diisocyanate; naphthylene diisocyanate; 2,6-tolylene diisocyanate; determination in urine; determination in blood; description of technique; 2,4-tolylene diisocyanate
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Isocyanates
Cyano compounds