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Document ID (ISN)104896
CIS number 06-376
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2005
Convention or series no.
Author(s) Ichihara G.
Title Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane
Bibliographic information Mar. 2005, Vol.78, No.2, p.79-96. 94 ref.
Abstract 2-Bromopropane (2-BP), used as an alternative to chlorofluorocarbons in a Korean electronics factory, caused reproductive and haematopoietic disorders in male and female workers. After identification of 2-BP toxicity, 1-bromopropane (1-BP) was introduced as an alternative. 1-BP was considered less mutagenic than 2-BP, but subsequent animal experiments revealed 1-BP to be a potent neurotoxic substance. It was also revealed that 1-BP has reproductive toxicity, but with target cells that are different from those of 2-BP. After the first animal study describing the neurotoxicity of 1-BP, human cases were reported showing decreased vibration perception, paraesthesia in the lower extremities, decreased sensation in the thighs, ventral and gluteal regions, stumbling and headache, as well as mucosal irritation. More work is necessary on the dose-response of bromopropanes in humans and on the mechanisms underlying the differences in toxic effects between the two bromopropanes.
Descriptors (primary) neurotoxic effects; 2-bromopropane; electronics industry; Korea, Republic of; 1-bromopropane; antifertility effects
Descriptors (secondary) mutagenic effects; chlorofluoroethanes; irritation; migraine; vertigo; sensation tests; vibration sensitivity; sensation thresholds; animal experiments; haematotoxic effects; paraesthesia
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Antifertility and prenatal effects
Halogenated hydrocarbons
Manufacturing of electrical appliances and equipment
Electronics industry
Genetic factors in reaction to exposures