|Document ID (ISN)||104892|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Enzymes as occupational and environmental respiratory sensitisers
||May 2005, Vol.78, No.4, p.279-286. Illus. 41 ref.
||Airborne enzymes occurring in the general environment and in purified form in industrial production have a high allergenic potential to the airways and mucous membranes, causing rhinitis, conjunctivitis and asthma. It can be assumed that this also applies to the increasing number of enzymes manufactured by the cloning of genetically engineered microorganisms. Cross-sectional studies demonstrate exposure-response relations for IgE-mediated sensitization and airway disorders. Atopic individuals are more susceptible to enzyme allergy than non-atopic individuals. Skin prick testing and measurement of specific IgE antibodies have been shown to be useful diagnostic tools. Very high concentrations of proteases may lead to emphysema. There is also evidence of non-allergic airway inflammation by proteases. It is recommended that all enzymes be classified with the risk phrase R42 (may cause sensitization by inhalation) and that their inhalation uptake be totally avoided.
||allergens; allergic respiratory disorders; sensitizers; enzymes
||literature survey; immunoglobulins; rhinitis; allergic asthma; biotechnology industry; diagnosis; individual susceptibility; inhalation toxicity; classification; emphysema
||D - Periodical articles
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)