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CISDOC database

Document ID (ISN)104864
CIS number 06-372
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2005
Convention or series no.
Author(s) Jarvis J., Seed M.J., Elton R.A., Sawyer L., Agius R.M.
Title Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds
Bibliographic information Apr. 2005, Vol.62, No.4, p.243-250. Illus. 31 ref.
Abstract The aim of this literature survey was to investigate relationships between chemical structure and reported occupational asthma for low molecular weight organic compounds. Nitrogen- or oxygen-containing functional groups such as isocyanates, amines, acid anhydrides and carbonyls were associated with occupational asthma, particularly when the functional group was present twice or more in the same molecule. Results suggest that chemical cross-linking is an important molecular mechanism leading to the development of occupational asthma.
Descriptors (primary) molecular structure; asthma; organic compounds
Descriptors (secondary) literature survey; carbonyls; statistical evaluation; amines; isocyanates; carboxylic acid anhydrides
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Inorganic substances
Diseases of the respiratory system (except for pneumoconiosis & similar)