|Document ID (ISN)||104863|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Lai C.H., Liou S.H., Lin H.C., Shih T.S., Tsai P.J., Chen J.S., Yang T., Jaakkola J.J.K., Strickland P.T.
||Exposure to traffic exhausts and oxidative DNA damage
||Apr. 2005, Vol.62, No.4, p.216-222. 31 ref.
||To assess the association between exposure to traffic exhausts and indicators of oxidative DNA damage, a case-control study was undertaken involving 47 female highway toll station workers and 27 female office workers as a reference group. Exposure assessment was based on average and cumulative traffic density and a biomarker of exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary 8-hydroxydeoxyguanosine (8-OHdG) was used as a biomarker of oxidative DNA damage. Plasma nitric oxide (NO) was measured as an indicator of oxidative stress related to traffic exhaust exposure. The mean concentration of urinary 8-OHdG was substantially higher among the exposed nonsmokers compared with the reference non-smokers. The mean concentration of NO among the exposed was also higher compared with the reference non-smokers. In linear regression adjusting for confounding, 8-OHdG was statistically significantly related to 1-OHPG. Results indicate that exposure to traffic exhausts increases oxidative DNA damage. Urinary 8-OHdG is a promising biomarker of traffic exhaust induced oxidative stress.
||DNA; exhaust gases; exposure tests; women; chromosome changes
||smoking; exposure evaluation; case-control study; nitric oxide; determination in blood; determination in urine; confounding factors
||D - Periodical articles
|Country / State or Province||United Kingdom; Taiwan (China); USA|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures