ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)104863
CIS number 06-371
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2005
Convention or series no.
Author(s) Lai C.H., Liou S.H., Lin H.C., Shih T.S., Tsai P.J., Chen J.S., Yang T., Jaakkola J.J.K., Strickland P.T.
Title Exposure to traffic exhausts and oxidative DNA damage
Bibliographic information Apr. 2005, Vol.62, No.4, p.216-222. 31 ref.
Abstract To assess the association between exposure to traffic exhausts and indicators of oxidative DNA damage, a case-control study was undertaken involving 47 female highway toll station workers and 27 female office workers as a reference group. Exposure assessment was based on average and cumulative traffic density and a biomarker of exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary 8-hydroxydeoxyguanosine (8-OHdG) was used as a biomarker of oxidative DNA damage. Plasma nitric oxide (NO) was measured as an indicator of oxidative stress related to traffic exhaust exposure. The mean concentration of urinary 8-OHdG was substantially higher among the exposed nonsmokers compared with the reference non-smokers. The mean concentration of NO among the exposed was also higher compared with the reference non-smokers. In linear regression adjusting for confounding, 8-OHdG was statistically significantly related to 1-OHPG. Results indicate that exposure to traffic exhausts increases oxidative DNA damage. Urinary 8-OHdG is a promising biomarker of traffic exhaust induced oxidative stress.
Descriptors (primary) DNA; exhaust gases; exposure tests; women; chromosome changes
Descriptors (secondary) smoking; exposure evaluation; case-control study; nitric oxide; determination in blood; determination in urine; confounding factors
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom; Taiwan (China); USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Biological monitoring