|Document ID (ISN)||104861|
|ISSN - Serial title
||1059-924X - Journal of Agromedicine
|Convention or series no.
||Lambert G.P., Spurzem J.R., Romberger D.J., Wyatt T.A., Lyden E., Stromquist A.M., Merchant J.A., Von Essen S.G.
||Tumor necrosis factor-α hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers
||2005, Vol.10, No.1, p.39-44. 30 ref.
||Many farmers present respiratory problems that may be related to workplace inhalation of organic dust containing endotoxins. The purpose of this study was to determine whether blood cytokine responsiveness to endotoxin is associated with respiratory disorders. 95 farmers completed a respiratory symptom questionnaire and were subjected to spirometry and blood sampling. Blood was incubated 24 hours in the presence and absence of endotoxin and analyzed for tumour necrosis factor-α (TNF-α). Hypo- or hyper-responsiveness to endotoxin was based on whether cytokine values were in the lower or upper 10% of the group range, respectively. A significant association existed between TNF-α hyper-responsiveness and chronic bronchitis. These results indicate that the blood cytokine assay may be useful to identify persons at risk of developing bronchitis following exposure to organic dust at the workplace.
||chronic bronchitis; exposure tests; agriculture; bacterial toxins
||extrinsic allergic alveolitis; interleukins; immunology; questionnaire survey; pulmonary function
||D - Periodical articles
|Country / State or Province||USA|
||Agriculture, fishing, animal husbandry
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)