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Document ID (ISN)104861
CIS number 06-446
ISSN - Serial title 1059-924X - Journal of Agromedicine
Year 2005
Convention or series no.
Author(s) Lambert G.P., Spurzem J.R., Romberger D.J., Wyatt T.A., Lyden E., Stromquist A.M., Merchant J.A., Von Essen S.G.
Title Tumor necrosis factor-α hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers
Bibliographic information 2005, Vol.10, No.1, p.39-44. 30 ref.
Abstract Many farmers present respiratory problems that may be related to workplace inhalation of organic dust containing endotoxins. The purpose of this study was to determine whether blood cytokine responsiveness to endotoxin is associated with respiratory disorders. 95 farmers completed a respiratory symptom questionnaire and were subjected to spirometry and blood sampling. Blood was incubated 24 hours in the presence and absence of endotoxin and analyzed for tumour necrosis factor-α (TNF-α). Hypo- or hyper-responsiveness to endotoxin was based on whether cytokine values were in the lower or upper 10% of the group range, respectively. A significant association existed between TNF-α hyper-responsiveness and chronic bronchitis. These results indicate that the blood cytokine assay may be useful to identify persons at risk of developing bronchitis following exposure to organic dust at the workplace.
Descriptors (primary) chronic bronchitis; exposure tests; agriculture; bacterial toxins
Descriptors (secondary) extrinsic allergic alveolitis; interleukins; immunology; questionnaire survey; pulmonary function
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Biological hazards
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological monitoring