| Document ID (ISN) | 104853 |
| CIS number |
06-365 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2005 |
| Convention or series no. |
|
| Author(s) |
Meuling W.J.A., Ravensberg L.C., Roza L., van Hemmen J.J. |
| Title |
Dermal absorption of chlorpyrifos in human volunteers |
| Bibliographic information |
Feb. 2005, Vol.78, No.1, p.44-50. Illus. 14 ref. |
| Abstract |
Doses of either 5mg or 15mg chlorpyrifos (CPF) diluted in ethanol were applied to the skin of healthy male volunteers. Duration of dermal exposure was 4h, after which the non-absorbed fraction was washed off. Urine samples of CPF and its metabolite 3,5,6-trichloro-2-pyridinol (TCP) were collected at pre-determined intervals up to 120h after application. A relatively large fraction of CPF (42%-67% of the applied dose) was washed off. There was no significant difference in total urinary excretion of TCP after 120h for the 5mg and 15mg CPF exposures, showing that an increase in the dermal dose does not increase absorption. Furthermore, it was observed that the clearance of CPF by the body was not completed within 120 h, suggesting that CPF or TCP was retained by the skin and/or accumulated in the body. Daily occupational exposure to CPF may therefore result in adverse effects. |
| Descriptors (primary) |
chlorpyrifos; exposure tests; urinary excretion; skin absorption |
| Descriptors (secondary) |
metabolic process; determination in urine; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Esters and salts
|
