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CISDOC database

Document ID (ISN)104827
CIS number 06-298
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Portengen L., Hollander A., Doekes G., de Meer G., Heederik D.
Title Lung function decline in laboratory animal workers: The role of sensitization and exposure
Bibliographic information Nov. 2003, Vol.60, No.11, p.870-875. 33 ref.
Abstract The relation between exposure and sensitization to laboratory animal allergens and changes in lung function was investigated in a longitudinal study (median follow up 2.0 years) among 319 laboratory animal workers. A total of 102 subjects who had been working with laboratory animals for less than four years were analysed separately, since an earlier cross sectional analysis had suggested a strong healthy worker effect in more experienced workers. In multiple regression analyses, both sensitization and exposure appeared to contribute independently to lung function decline, after adjusting for gender, age, smoking and atopy. Lung function decline was most pronounced in sensitized subjects who continued to be in contact with the animals to which they were sensitized.
Descriptors (primary) experimental animals; ventilatory capacity; sensitization; handling of animals; long-term exposure
Descriptors (secondary) allergens; healthy worker effect; symptoms; vital capacity; spirometry; questionnaire survey; long-term study; skin tests; one-second forced expiratory volume
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Occupational pathology
Broad subject area(s) Biological hazards
Occupational medicine, epidemiology
Browse category(ies) Livestock rearing
Animal hazards