|Document ID (ISN)||104827|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Portengen L., Hollander A., Doekes G., de Meer G., Heederik D.
||Lung function decline in laboratory animal workers: The role of sensitization and exposure
||Nov. 2003, Vol.60, No.11, p.870-875. 33 ref.
||The relation between exposure and sensitization to laboratory animal allergens and changes in lung function was investigated in a longitudinal study (median follow up 2.0 years) among 319 laboratory animal workers. A total of 102 subjects who had been working with laboratory animals for less than four years were analysed separately, since an earlier cross sectional analysis had suggested a strong healthy worker effect in more experienced workers. In multiple regression analyses, both sensitization and exposure appeared to contribute independently to lung function decline, after adjusting for gender, age, smoking and atopy. Lung function decline was most pronounced in sensitized subjects who continued to be in contact with the animals to which they were sensitized.
||experimental animals; ventilatory capacity; sensitization; handling of animals; long-term exposure
||allergens; healthy worker effect; symptoms; vital capacity; spirometry; questionnaire survey; long-term study; skin tests; one-second forced expiratory volume
||D - Periodical articles
|Country / State or Province||Netherlands|
|Broad subject area(s)
Occupational medicine, epidemiology