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Document ID (ISN)104674
CIS number 06-141
ISSN - Serial title 1077-3525 - International Journal of Occupational and Environmental Health
Year 2004
Convention or series no.
Author(s) Liu Y., Berode M., Stowe M.H., Holm C.T., Walsh F.X., Slade M.D., Boeniger M.F., Redlich C.A.
Title Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: A human inhalation study
Bibliographic information July-Sep. 2004, Vol.10, No.3, p.262-271. Illus. 34 ref.
Internet access http://www.ijoeh.com/pfds/1003_Liu.pdf [in English]
Abstract The use of urinary hexane diamine (HDA) as a biomarker to assess respiratory exposure to hexamethylene diisocyanate (HDI) aerosol was evaluated. Twenty-three auto body shop workers were exposed for two hours to HDI biuret aerosol. HDI exposures were quantified. Urine samples were collected at baseline, immediately post exposure, and every 4-5 hours up to 20 hours and analyzed for HDA using gas chromatography and mass spectrometry. Mean urinary HDA (mgg/g creatinine) increased sharply from the baseline value of 0.7 to 18.1 post exposure and decreased rapidly to 4.7, 1.9 and 1.1, respectively, at 4, 9 and 18 hours post exposure. Considerable individual variability was found. Urinary HDA can assess acute respiratory exposure to HDI aerosol but may however have limited use as a biomarker of exposure in the workplace.
Descriptors (primary) hexamethylene diisocyanate; exposure tests; aerosols
Descriptors (secondary) mass spectrometry; hexamethylene diisocyanate biuret; exposure evaluation; determination in urine; description of technique; gas chromatography; determination in air
Document type D - Periodical articles
Country / State or ProvinceSwitzerland; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Isocyanates
Cyano compounds