|Document ID (ISN)||104674|
|ISSN - Serial title
||1077-3525 - International Journal of Occupational and Environmental Health
|Convention or series no.
||Liu Y., Berode M., Stowe M.H., Holm C.T., Walsh F.X., Slade M.D., Boeniger M.F., Redlich C.A.
||Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: A human inhalation study
||July-Sep. 2004, Vol.10, No.3, p.262-271. Illus. 34 ref.
||http://www.ijoeh.com/pfds/1003_Liu.pdf [in English]
||The use of urinary hexane diamine (HDA) as a biomarker to assess respiratory exposure to hexamethylene diisocyanate (HDI) aerosol was evaluated. Twenty-three auto body shop workers were exposed for two hours to HDI biuret aerosol. HDI exposures were quantified. Urine samples were collected at baseline, immediately post exposure, and every 4-5 hours up to 20 hours and analyzed for HDA using gas chromatography and mass spectrometry. Mean urinary HDA (mgg/g creatinine) increased sharply from the baseline value of 0.7 to 18.1 post exposure and decreased rapidly to 4.7, 1.9 and 1.1, respectively, at 4, 9 and 18 hours post exposure. Considerable individual variability was found. Urinary HDA can assess acute respiratory exposure to HDI aerosol but may however have limited use as a biomarker of exposure in the workplace.
||hexamethylene diisocyanate; exposure tests; aerosols
||mass spectrometry; hexamethylene diisocyanate biuret; exposure evaluation; determination in urine; description of technique; gas chromatography; determination in air
||D - Periodical articles
|Country / State or Province||Switzerland; USA|
||Toxic and dangerous substances
|Broad subject area(s)