| Document ID (ISN) | 104651 |
| CIS number |
06-132 |
| ISSN - Serial title |
1231-868X - Podstawy i Metody Oceny Środowiska Pracy |
| Year |
2005 |
| Convention or series no. |
|
| Author(s) |
Sitarek K. |
| Title |
N-Methyl-2-pyrrolidone: Documentation of maximum admissible values for occupational exposure |
| Original title |
1-Metylo-2-pirolidon: Dokumentacja proponowanych wartości dopuszczalnych wielkości narażenia zawodowego [in Polish] |
| Bibliographic information |
2005, Vol.43, No.1, p.103-115. 26 ref. |
| Abstract |
N-methyl-2-pyrrolidone (methylpyrrolidinone, NMP) is an industrial solvent. It can be absorbed through the skin. The substance is not mutagenic, genotoxic or carcinogenic but it is embryotoxic, foetotoxic and teratogenic at doses which are non-toxic to the mothers. On the basis that it disturbs prenatal development in more than one animal species, in the Scandinavian countries NMP has been classified in the IB group, which comprises substances probably harmful to human reproduction. Based on the NOAEL value obtained in an experimental study (500 mg/m3) and appropriate uncertainty factors, a TLV of 120 mg/m3 and a short-term exposure level of 240 mg/m3 have been proposed. In addition, notations are suggested for irritation, foetotoxicity and skin absorption. |
| Descriptors (primary) |
toxic effects; threshold limit values; methylpyrrolidinone; solvents; toxicology |
| Descriptors (secondary) |
embryotoxic effects; irritants; teratogenic effects; skin absorption; Poland |
| Document type |
D - Periodical articles |
| Country / State or Province | Poland |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Heterocyclic compounds
Genetic factors in reaction to exposures
Occupational exposure limits
|
