|Document ID (ISN)||104618|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Goldstein D.A., Shelton P.E., Cullen M.R., Easterday P.A., Eppard P.J., Cabanilla B.R.
||Responding to the challenge of novel technology: An industrial hygiene and safety program for antibody production in maize
||Aug. 2004, Vol.46, No.8, p.784-790. Illus. 32ref.
||This article examines the challenges to occupational hygiene and safety posed by biotechnology, in particular the production of pharmaceutical proteins in plants. These challenges include: the widely varying potential for hazard depending on the activity of the protein and the nature and location of the target organ; limited data relating to industrial routes of exposure; and the inability to obtain relevant animal data because of high species-specificity. An approach to industrial hygiene and safety in this area is proposed based on the systematic assessment of employee risk using conservative assumptions and on the management of exposure. The method is described with reference to the production of monoclonal antibodies in maize.
||pharmaceutical products; proteins; biotechnology industry; exposure evaluation; biological hazards; limitation of exposure
||airborne dust; routes of entry; maize; medical supervision; pollen; biological effects; antibodies
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)