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Document ID (ISN)104618
CIS number 06-90
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Goldstein D.A., Shelton P.E., Cullen M.R., Easterday P.A., Eppard P.J., Cabanilla B.R.
Title Responding to the challenge of novel technology: An industrial hygiene and safety program for antibody production in maize
Bibliographic information Aug. 2004, Vol.46, No.8, p.784-790. Illus. 32ref.
Abstract This article examines the challenges to occupational hygiene and safety posed by biotechnology, in particular the production of pharmaceutical proteins in plants. These challenges include: the widely varying potential for hazard depending on the activity of the protein and the nature and location of the target organ; limited data relating to industrial routes of exposure; and the inability to obtain relevant animal data because of high species-specificity. An approach to industrial hygiene and safety in this area is proposed based on the systematic assessment of employee risk using conservative assumptions and on the management of exposure. The method is described with reference to the production of monoclonal antibodies in maize.
Descriptors (primary) pharmaceutical products; proteins; biotechnology industry; exposure evaluation; biological hazards; limitation of exposure
Descriptors (secondary) airborne dust; routes of entry; maize; medical supervision; pollen; biological effects; antibodies
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) New technologies
Browse category(ies) Exposure evaluation
Biotechnology industry
Biological hazards