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Document ID (ISN)104617
CIS number 06-201
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Magnusson L.L., Bonde J.P., Olsen J., M÷ller L., Bingefors K., Wennborg H.
Title Paternal laboratory work and congenital malformations
Bibliographic information Aug. 2004, Vol.46, No.8, p.761-767. Illus. 43 ref.
Abstract A study was carried out on male employees of biological and biomedical institutions in Swedish universities from 1970 to 1989. A control group comprised workers in non-biological departments of the same universities. Female partners were linked to the Swedish Medical Birth register. The total number of pregnancies available for study was 4170. The relationship between major malformations and exposure to laboratory work and to specific laboratory agents or techniques before the third trimester of pregnancy was analysed using logistic regression. There were a total of 81 births with at least one major malformation: 44 among those exposed to paternal laboratory work and 37 among the reference group. It was concluded that while the prevalence of congenital malformations was not increased in the offspring of male laboratory workers in general, paternal work with agents such as carcinogens could be of concern.
Descriptors (primary) carcinogens; male workers; teratogenic effects; laboratory work; parental exposure
Descriptors (secondary) Sweden; epidemiologic study; organic solvents; radioactive substances
Document type D - Periodical articles
Country / State or ProvinceDenmark; Sweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Biological hazards
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects