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Document ID (ISN)104564
CIS number 06-105
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Lebailly P., Devaux A., Pottier D., De Meo M., Andre V., Baldi I., Severin F, Bernaud J., Durand B., Henry-Amar M., Gauduchon P.
Title Urine mutagenicity and lymphocyte DNA damage in fruit growers occupationally exposed to the fungicide captan
Bibliographic information Dec. 2003, Vol.60, No.12, p.910-917. Illus. 39 ref.
Abstract The objective of this study was to determine haematological parameters, urine mutagenicity (on three Salmonella typhimurium strains), and DNA damage (using the comet assay) in mononuclear leucocytes of farmers before and after a one-day spraying period of pear and apple trees with the fungicide captan in usual conditions. A total of 19 farmers were exposed to captan during the 1998 and the 2000 spraying seasons. It was found that one-day spraying periods with captan and other pesticides does not significantly induce DNA damages in mononuclear leucocytes. In contrast, inefficient protective clothing could correlate with an increase in urine mutagenicity.
Descriptors (primary) mutagenic effects; captan; pesticide spraying; orchards; cytogenetic studies; agriculture
Descriptors (secondary) leukocytes; France; blood cytology; mutagenicity tests; urine cytology; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Agriculture, fishing, animal husbandry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures