|Document ID (ISN)||104518|
|ISSN - Serial title
||0535-5133 - Investigación Clínica
|Convention or series no.
||Díaz-Valecillos M., Fernández J., Rojas A., Valecillos J., Cañizales J.
||Chromosome alterations in workers exposed to ionizing radiation
||Alteraciones cromosómicas en trabajadores expuestos a radiaciones ionizantes [in Spanish]|
||Sep. 2004, Vol.45, No.3, p.197-211. 39 ref.
||The objective of this study was to examine and characterize chromosome alterations and their relationship with radiation doses, length of occupational exposure and length of weekly exposure. It involved 18 Venezuelan petroleum industry workers exposed to ionizing radiation for at least one year and a control group of randomly selected non-exposed workers. For the exposed group, average age was 46.1 years, duration of employment was 17.5 years and weekly exposure was 4.3 hours. Chromosomal anomalies consisted of simple fragilities (66%) and combined fragilities with chromosome breaks, deletions and polyploidies (22%). Among controls, chromosome alterations consisted of simple fragilities in 55% of cases. Among radiologists, 88.8% of the chromosome alterations were found for doses below permissible levels. 88% of the radiologists showing anomalies had been exposed for over 10 years. The results indicate that, depending on the duration of employment and weekly exposures, chronic exposure to low doses of ionizing radiation may cause chromosome alterations.
||chromosome changes; ionizing radiation
||case-control study; dose-response relationship; length of exposure; dosimetry
||D - Periodical articles
|Country / State or Province||Venezuela|
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures