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Document ID (ISN)104518
CIS number 06-178
ISSN - Serial title 0535-5133 - Investigación Clínica
Year 2004
Convention or series no.
Author(s) Díaz-Valecillos M., Fernández J., Rojas A., Valecillos J., Cañizales J.
Title Chromosome alterations in workers exposed to ionizing radiation
Original title Alteraciones cromosómicas en trabajadores expuestos a radiaciones ionizantes [in Spanish]
Bibliographic information Sep. 2004, Vol.45, No.3, p.197-211. 39 ref.
Abstract The objective of this study was to examine and characterize chromosome alterations and their relationship with radiation doses, length of occupational exposure and length of weekly exposure. It involved 18 Venezuelan petroleum industry workers exposed to ionizing radiation for at least one year and a control group of randomly selected non-exposed workers. For the exposed group, average age was 46.1 years, duration of employment was 17.5 years and weekly exposure was 4.3 hours. Chromosomal anomalies consisted of simple fragilities (66%) and combined fragilities with chromosome breaks, deletions and polyploidies (22%). Among controls, chromosome alterations consisted of simple fragilities in 55% of cases. Among radiologists, 88.8% of the chromosome alterations were found for doses below permissible levels. 88% of the radiologists showing anomalies had been exposed for over 10 years. The results indicate that, depending on the duration of employment and weekly exposures, chronic exposure to low doses of ionizing radiation may cause chromosome alterations.
Descriptors (primary) chromosome changes; ionizing radiation
Descriptors (secondary) case-control study; dose-response relationship; length of exposure; dosimetry
Document type D - Periodical articles
Country / State or ProvinceVenezuela
Subject(s) Radiation
Broad subject area(s) Physical hazards
Browse category(ies) Antifertility and prenatal effects
Ionizing radiation
Genetic factors in reaction to exposures