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CISDOC database

Document ID (ISN)104409
CIS number 05-662
ISBN(s) 2-551-22745-3
Year 2005
Convention or series no. Etudes et Recherches R-419
Author(s) Ostiguy C., Gagné S., Lesage J., Van Tra H., Cloutier Y.
Title Development of a highly sensitive analytical method for isocyanates
Original title Développement d'une méthode d'analyse d'isocyanates à très haute sensibilité [in French]
Bibliographic information Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, 2005. 44p. Illus. 82 ref. Price: CAD 6.42. Downloadable version (PDF format) free of charge.
Internet access [in French]
Abstract Isocyanates are lung and skin irritants and sensitizers that can cause many diseases, occupational asthma being the most serious. Current methods for determining these substances are often of limited use due to their inadequate sensitivity. This report describes the development of an analytical method to detect low levels of isocyanate in industrial settings. It is based on high-pressure liquid chromatography coupled with mass spectrometry. Sampling is carried out with single-membrane reactive cassettes. The method provides a useful tool for making decisions regarding appropriate personal protective equipment, safer work organization, reassignment of sensitized workers and identification of levels of non-reacted isocyanates in various materials.
Descriptors (primary) isocyanates; description of technique; determination in air; sampling and analysis
Descriptors (secondary) irritants; mass spectrometry; high-pressure liquid chromatography; sensitizers; personal protective equipment; report
Document type E - Books, reports, proceedings
Country / State or ProvinceCanada
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Isocyanates
Cyano compounds