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Document ID (ISN)104401
CIS number 05-657
ISBN(s) 2-551-22697-X
Year 2005
Convention or series no. Etudes et Recherches R-403
Author(s) Lacasse Y., Martin S., Desmeules M.
Title Silicosis, silica and lung cancer: Meta-analysis of medical literature
Original title Silicose, silice et cancer du poumon: méta-analyse de la littérature médicale [in French]
Bibliographic information Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, 2005. iv, 91p. Illus. 128 ref. + CD-ROM. Price: CAD 10.70. Downloadable version (PDF format) free of charge.
Internet access [in French]
Abstract Despite significant efforts to limit exposure to silica, 494 new cases of silicosis were diagnosed in Quebec between 1988 and 2003. While the CSST acknowledges the existence of a relationship between silica exposure and certain cases of lung cancer, this view is not unanimously accepted by lung specialists. This study examines the literature concerning the relationship between silicosis, exposure to silica and lung cancer. Findings suggest that there is an increased risk of death due to lung cancer in silicotic persons. The data published to date also suggest that silica exposure represents a low risk factor for lung cancer at exposure concentrations that exceed the permitted limit based on North American standards. These results are broadly in agreement with the conclusions of the International Agency for Research on Cancer (IARC).
Descriptors (primary) silica; risk factors; silicosis; lung cancer
Descriptors (secondary) literature survey; threshold limit values; compensation of occupational diseases; frequency rates; report; IARC; Quebec
Document type E - Books, reports, proceedings
Country / State or ProvinceCanada
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Pneumoconioses
Diseases of the respiratory system (except for pneumoconiosis & similar)