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Document ID (ISN)104380
CIS number 05-632
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2003
Convention or series no.
Author(s) Altindag Z.Z., Baydar T., Isimer A., Sahin G.
Title Neopterin as a biomarker for the evaluation of occupational exposure to silica
Bibliographic information May 2003, Vol.76, No.4, p.318-322. Illus. 26 ref.
Abstract The aim of this study was to measure neopterin levels among workers exposed to silica and also to examine whether these measurements would be of use in assessing occupational exposure to silica. Serum and urinary neopterin levels of 22 silica-exposed workers and 20 unexposed healthy volunteers were investigated by immunoassay, spectrophotometry and high-performance liquid chromatography techniques. In the control and exposed groups of workers, serum neopterin levels were 5.98▒0.44 and 7.86▒1.97nmol/l, respectively while urinary neopterin levels were 97.60▒41.42nol/mol creatinine and 165.59▒78.20Ámol/mol creatinine respectively. Correlations between urinary neopterin levels, serum neopterin concentration and working years, smoking status, self-reported complaints, and silica in the working atmosphere were also evaluated. The findings suggest that follow up of neopterin levels may have diagnostic value in silica-related diseases such as silicosis.
Descriptors (primary) silica; foundries; exposure tests; respirable dust
Descriptors (secondary) Turkey; silicosis; case-control study; determination in urine; length of exposure; determination in air; determination in blood; immunology
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Foundries, metalcasting and forging operations
Biological monitoring