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CISDOC database

Document ID (ISN)104371
CIS number 05-628
ISSN - Serial title 1047-322X - Applied Occupational and Environmental Hygiene
Year 2003
Convention or series no.
Author(s) Qu Q., Cohen B.S., Shore R., Chen L.C., Li G., Jin X., Melikian A.A., Yin S., Yan H., Xu B., Li Y., Mu R., Zhang X., Li K.
Title Benzene exposure measurement in shoe and glue manufacturing: A study to validate biomarkers
Bibliographic information Dec. 2003, Vol.18, No.12, p.988-998. Illus. 9 ref.
Abstract The aim of this study was to determine whether selected biological markers of exposure to benzene are reliable and sensitive enough to detect low-level exposures. Recruitment of 130 exposed subjects was based on personal exposure measurements collected for three to four weeks prior to collection of biological samples. Personal exposure to benzene was monitored between 1997 and 1998 and results were correlated with the concentrations of two urinary benzene metabolites, trans, trans-muconic acid and S-phenylmercapturic acid. Results indicated that S-phenylmercapturic acid appears to be a good biomarker for detecting and evaluating benzene exposure at concentrations less than 0.25ppm.
Descriptors (primary) China; benzene; shoe industry; exposure tests; adhesives
Descriptors (secondary) S-phenylmercapturic acid; personal sampling; toluene; xylene; determination in urine; urinary metabolites; dose-response relationship; determination in air; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceChina; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Aromatic hydrocarbons
Footwear, leather and fur industry