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CISDOC database

Document ID (ISN)104323
CIS number 05-622
ISSN - Serial title 1047-322X - Applied Occupational and Environmental Hygiene
Year 2002
Convention or series no.
Author(s) Ott M.G.
Title Occupational asthma, lung function decrement, and toluene diisocyanate (TDI) exposure: A critical review of exposure-response relationships
Bibliographic information Dec. 2002, Vol.17, No.12, p.891-901. 73 ref.
Abstract This literature review on the effects of toluene diisocyanate (TDI) exposure on respiratory health focused on bronchial asthma and the accelerated decline in lung function. In the early years of the industry, annual incidence rates of TDI-induced occupational asthma (OA) were as high as 5-6 percent. In settings where mean TDI concentrations have been maintained below 5ppb, OA incidence rates have declined to below 1% annually. Studies from the 1960s and 1970s that examined lung function decrement provided evidence of a decline in forced expiratory volume in one second (FEV1) during periods of ongoing exposure among employees experiencing high rates of work-related symptoms of OA. More recent studies have provided no consistent evidence of accelerated FEV1 loss among employees exposed up to 5ppb TDI (8-hr TWA) even with documented routine short-term TDI concentrations exceeding 20ppb.
Descriptors (primary) tolylene diisocyanate; pulmonary function; asthma
Descriptors (secondary) literature survey; threshold limit values; dose-response relationship; one-second forced expiratory volume; respiratory function tests; symptoms
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds