|Document ID (ISN)||104323|
|ISSN - Serial title
||1047-322X - Applied Occupational and Environmental Hygiene
|Convention or series no.
||Occupational asthma, lung function decrement, and toluene diisocyanate (TDI) exposure: A critical review of exposure-response relationships
||Dec. 2002, Vol.17, No.12, p.891-901. 73 ref.
||This literature review on the effects of toluene diisocyanate (TDI) exposure on respiratory health focused on bronchial asthma and the accelerated decline in lung function. In the early years of the industry, annual incidence rates of TDI-induced occupational asthma (OA) were as high as 5-6 percent. In settings where mean TDI concentrations have been maintained below 5ppb, OA incidence rates have declined to below 1% annually. Studies from the 1960s and 1970s that examined lung function decrement provided evidence of a decline in forced expiratory volume in one second (FEV1) during periods of ongoing exposure among employees experiencing high rates of work-related symptoms of OA. More recent studies have provided no consistent evidence of accelerated FEV1 loss among employees exposed up to 5ppb TDI (8-hr TWA) even with documented routine short-term TDI concentrations exceeding 20ppb.
||tolylene diisocyanate; pulmonary function; asthma
||literature survey; threshold limit values; dose-response relationship; one-second forced expiratory volume; respiratory function tests; symptoms
||D - Periodical articles
|Country / State or Province||USA|
Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)