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CISDOC database

Document ID (ISN)104322
CIS number 05-645
ISSN - Serial title 1047-322X - Applied Occupational and Environmental Hygiene
Year 2002
Convention or series no.
Author(s) Diller W.F.
Title Frequency and trends of occupational asthma due to toluene diisocyanate: A critical review
Bibliographic information Dec. 2002, Vol.17, No.12, p.872-877. Illus. 35 ref.
Abstract Reports and statements on the frequency of occupational asthma due to isocyanates are contradictory. In order to clarify the issue, a critical review of the medical literature of the past half-century worldwide has been performed, with special emphasis on toluene diisocyanate (TDI) as the main representative of the isocyanate family. Nine longitudinal workplace studies of 2751 persons under risk allowed the calculation of incidences of occupational asthma due to TDI. Annual incidences were repeatedly above 5% before 1980, and have decreased to between 0 and 0.7% since 1980. Prevalences of occupational asthma due to TDI were estimated from ten cross-sectional studies, based on 788 persons. Prevalences were repeatedly above 10% before 1985, and have been mostly between 0 and 10% in recent years.
Descriptors (primary) asthma; tolylene diisocyanate
Descriptors (secondary) literature survey; statistical trends; frequency rates; long-term study; cross-sectional study
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds