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Document ID (ISN)104306
CIS number 05-619
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Luo J.C., Cheng T.J., Kuo H.W., Chang M.J.W.
Title Decreased lung function associated with occupational exposure to epichlorohydrin and the modification effects of glutathione S-transferase polymorphisms
Bibliographic information Mar. 2004, Vol.46, No.3, p.280-286. 45 ref.
Abstract Epichlorohydrin (ECH) is a strong irritant of the eyes, respiratory tract, and skin. Because the toxic effect of various chemicals can be modified by metabolic traits, this study investigated the influence of the glutathione S-transferase (GSTM1 and GSTT1) genes on the toxic effect of ECH. In the GSTM1 null genotype workers, there is a dose-response of lung function tests for ECH exposure, but not in the GSTM1 non-null genotype workers. The ECH exposure was found to be significantly associated with decreased FEV1 and MMEF values after adjusting for other factors. The GSTM1 null genotype was found to be significantly associated with decreased FEV1, FEV1/FVC and MMEF values after adjusting for other factors. This study indicates that obstructive lung abnormalities and small airway lung damage are associated with ECH exposure, and ECH workers with GSTM1 null-type are also associated with increased respiratory damage.
Descriptors (primary) chemical industry; individual susceptibility; pulmonary function; epichlorohydrin
Descriptors (secondary) irritants; Taiwan (China); maximal expiratory flow; respiratory impairment; exposure evaluation; respiratory function tests; one-second forced expiratory volume
Document type D - Periodical articles
Country / State or ProvinceTaiwan (China)
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Ethers
Ethylene oxide