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Document ID (ISN)104268
CIS number 05-520
ISSN - Serial title 1231-868X - Podstawy i Metody Oceny Środowiska Pracy
Year 2002
Convention or series no.
Author(s) Piotrowski J., Szymańska J.
Title 4'-Ethoxyacetanilide
Original title 4'-Etoksyacetanilid [in Polish]
Bibliographic information 2002, Vol.33, No.3, p.119-137. 37 ref.
Abstract Phenacetin (4'-ethoxyacetanilide) is mainly used as analgesic and antipyretic. Acute intoxications are characterized by skin eruptions, methaemoglobinaemia, haemolytic anaemia, headache, dizziness and the necrosis of renal mammilla. Consumption of phenacetin in high doses (at least 1g/day) for extended periods results in renal insufficiency. Epidemiological studies indicate that nephropathies caused by analgesics represent 1-20% of all nephropathies. Necrosis of the kidneys may result in renal cancer. On the basis of epidemiological data, the short-tem exposure limit value was set at 5mg/m3 for phenacetin dust.
Descriptors (primary) Poland; health hazards; toxicology; phenacetin
Descriptors (secondary) literature survey; methaemoglobinaemia; analgesics; haemolytic anaemia; migraine; symptoms; renal cancer; renal insufficiency; skin eruption; necrosis; vertigo; permissible levels; animal experiments; determination of exposure limits; nephrotoxic effects; criteria document; threshold limit values
Document type B - Chemical safety information sheets
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Amides