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Document ID (ISN)104205
CIS number 05-399
ISBN(s) 3-86509-110-5
Year 2004
Convention or series no. Fb 1009
Author(s) Akkan Z., Kalberlah F., Oltmanns J., Schneider K.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Title Potency assessment of skin sensitizing chemicals using the local lymph node assay
Original title Beurteilung der Wirkstärke hautsensibilisierender Chemikalien anhand des Local Lymph Node Assay [in German]
Bibliographic information Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2004. 303p. Illus. Approx. 250 ref. Price: EUR 23.50.
Abstract The local lymph node assay (LLNA) is a relatively recent method for determining the degree of skin sensitization in mice. This study aimed at establishing correlations between results obtained by this method and those of human sensitization studies (human repeat insult patch tests and human maximization tests). For this purpose, results of LLNA tests and human tests were compared for 46 sensitizers. The degree of sensitization induced by these substances ranged through four levels of magnitude. Very good correlations were observed between LLNA tests and human tests. Four classes of classification are proposed for the degree of sensitization (low, medium, strong and very strong).
Descriptors (primary) eczema; sensitizers; sensitization; skin tests; chemical products
Descriptors (secondary) lymph nodes; Germany; toxicology; comparative study; animal experiments; classification; allergic reactivity; hazard evaluation
Document type E - Books, reports, proceedings
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases