| Document ID (ISN) | 104131 |
| CIS number |
05-370 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2003 |
| Convention or series no. |
|
| Author(s) |
Kawai T., Zhang Z.W., Takeuchi A., Miyama Y., Sakamoto K., Higashikawa K., Ikeda M. |
| Title |
Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels |
| Bibliographic information |
Feb. 2003, Vol.76, No.1, p.17-23. Illus. 46 ref. |
| Abstract |
To examine whether urinary methyl isobutyl ketone (MIBK) and methyl ethyl ketone (MEK) are useful markers of low-level occupational exposure to these solvents, 27 furniture-making workers (19 men and eight women) and 11 non-exposed controls (six men and five women) volunteered to participate in this study. Eight-hour time-weighted average (TWA) concentrations of solvent vapours in air were monitored by diffusive sampling. Urine samples collected at the end of the shift were subjected to gas chromatography analysis. The relationship between the solvent concentrations and the corresponding urinary levels was examined by simple as well as multiple regression analysis. Significant correlations were found for both MIBK and MEK. It is concluded that urinary concentrations are good markers of exposure to both solvents. |
| Descriptors (primary) |
butanone; exposure tests; hexone |
| Descriptors (secondary) |
solvents; exposure evaluation; determination in urine; statistical evaluation; gas chromatography; dose-response relationship |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Ketones
|
