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Document ID (ISN)104124
CIS number 05-292
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2005
Convention or series no.
Author(s) Piirilń P., Lindqvist M., Huuskonen O., Kaleva S., Koskinen H., Lehtola H., Vehmas T., Kivissari L., Sovijńrvi A.R.A.
Title Impairment of lung function in asbestos-exposed workers in relation to high-resolution computed tomography
Bibliographic information Feb. 2005, Vol.31, No.1, p.44-51. 33 ref.
Abstract The aim of the study was to determine the causes of impairment of ventilatory function and diffusing capacity in 590 smoking asbestos-exposed workers showing radiological pleural thickenings or pulmonary fibrosis. High-resolution computed tomography (HRCT) and spirometry were performed, and diffusing capacity was measured. The workers were divided into five groups based on the HRCT scoring: pleural disease (190), pulmonary fibrosis (68), emphysema (148), combined fibrosis and emphysema (74), and marked adhesions (110). Graded lung function impairment was compared among the groups. Moderate impairment of forced expiratory volume in one second (odds ratio (OR) 2.72) and forced vital capacity (OR 2.81) was associated with persons with combined fibrosis and emphysema. Marked impairment of diffusing capacity was associated with combined fibrosis and emphysema (OR 4.94) but not with pleural disease (OR 0.21) or pulmonary fibrosis (OR 0.36). For persons with combined fibrosis and emphysema, the mean fibrosis score did not differ between normal, slightly reduced, or markedly reduced diffusing capacity, but the emphysema score was significantly higher for patients with marked impairment than for those with normal diffusing capacity. The results indicate that the most important factor determining the degree of functional impairment in smoking asbestos-exposed workers is the presence of pulmonary emphysema
Descriptors (primary) diffusion capacity; pulmonary function; smoking; asbestos
Descriptors (secondary) maximal expiratory flow; emphysema; pulmonary fibrosis; tomography; one-second forced expiratory volume; spirometry; pleural diseases
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Asbestos
Smoking