| Document ID (ISN) | 104111 |
| CIS number |
05-369 |
| ISSN - Serial title |
0105-1873 - Contact Dermatitis |
| Year |
2003 |
| Convention or series no. |
|
| Author(s) |
Frick M., Björkner B., Hamnerius N., Zimerson E. |
| Title |
Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate |
| Bibliographic information |
June 2003, Vol.48, No.6, p.305-309. 17 ref. |
| Abstract |
From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. 13 patients reacted to DMDI, nine to 1,6-hexamethylenediisocyanate (HDI) and four to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to aromatic isocyanates, diphenylmethane-4,4'-diisocyanate (MDI) or toluenediisocyanate (TDI). One explanation for this pattern could be that aromatic diisocyanates are more reactive and therefore inactivated before penetrating the skin. Five patients reacted to dicyclohexylmethane-4,4'-diamine (DMDA) and five to 4,4'-diaminodiphenylmethane (MDA). Concurrent reactions to DMDA and/or MDA with DMDI could be due to cross-reactivity. The positive reactions to MDA could also be a marker of MDI exposure. |
| Descriptors (primary) |
instrumentation industry; allergens; adhesives; eczema; isocyanates |
| Descriptors (secondary) |
Sweden; case study; skin tests; isophorone diisocyanate; skin absorption; hexamethylene diisocyanate |
| Document type |
D - Periodical articles |
| Country / State or Province | Sweden |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
Occupational medicine, epidemiology
|
| Browse category(ies) |
Cyano compounds
Skin diseases
Isocyanates
|
