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Document ID (ISN)104111
CIS number 05-369
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2003
Convention or series no.
Author(s) Frick M., Bj÷rkner B., Hamnerius N., Zimerson E.
Title Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate
Bibliographic information June 2003, Vol.48, No.6, p.305-309. 17 ref.
Abstract From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. 13 patients reacted to DMDI, nine to 1,6-hexamethylenediisocyanate (HDI) and four to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to aromatic isocyanates, diphenylmethane-4,4'-diisocyanate (MDI) or toluenediisocyanate (TDI). One explanation for this pattern could be that aromatic diisocyanates are more reactive and therefore inactivated before penetrating the skin. Five patients reacted to dicyclohexylmethane-4,4'-diamine (DMDA) and five to 4,4'-diaminodiphenylmethane (MDA). Concurrent reactions to DMDA and/or MDA with DMDI could be due to cross-reactivity. The positive reactions to MDA could also be a marker of MDI exposure.
Descriptors (primary) instrumentation industry; allergens; adhesives; eczema; isocyanates
Descriptors (secondary) Sweden; case study; skin tests; isophorone diisocyanate; skin absorption; hexamethylene diisocyanate
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Skin diseases
Isocyanates
Cyano compounds