|Document ID (ISN)||104111|
|ISSN - Serial title
||0105-1873 - Contact Dermatitis
|Convention or series no.
||Frick M., Bj÷rkner B., Hamnerius N., Zimerson E.
||Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate
||June 2003, Vol.48, No.6, p.305-309. 17 ref.
||From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. 13 patients reacted to DMDI, nine to 1,6-hexamethylenediisocyanate (HDI) and four to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to aromatic isocyanates, diphenylmethane-4,4'-diisocyanate (MDI) or toluenediisocyanate (TDI). One explanation for this pattern could be that aromatic diisocyanates are more reactive and therefore inactivated before penetrating the skin. Five patients reacted to dicyclohexylmethane-4,4'-diamine (DMDA) and five to 4,4'-diaminodiphenylmethane (MDA). Concurrent reactions to DMDA and/or MDA with DMDI could be due to cross-reactivity. The positive reactions to MDA could also be a marker of MDI exposure.
||instrumentation industry; allergens; adhesives; eczema; isocyanates
||Sweden; case study; skin tests; isophorone diisocyanate; skin absorption; hexamethylene diisocyanate
||D - Periodical articles
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology