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Document ID (ISN)104101
CIS number 05-254
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2005
Convention or series no. Fascicule 16050A 10, 1-2005
Author(s) Saillenfait A.M., Laudet-Hesbert A.
Title Phthalates
Original title Phtalates [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 1st Quarter 2005, No.146, 9p. 102 ref.
Abstract Phthalic esters or organic phthalates consist of a family of chemicals that are widely used, mainly as PVC plasticizers for numerous consumer and industrial products. Their volatility and water solubility are low. This information note covers the six phthalates whose use is currently the most important. Among rodents, the main observed toxic effects concern the liver, and include liver tumours in the case of diisononyl phthalate and di-(2-ethylhexyl) phthalate. However, it is generally accepted that in view of the mode of action of these substances these effects cannot be extrapolated to humans. The effects of certain phthalates that are the cause of most concern relate to reproductive and pre-birth developmental effects: di-n-butyl phthalate, butyl benzyl phthalate and di-(2-ethylhexyl) phthalate can affect the male reproductive system (both during development and among adults) and are embryotoxic and foetotoxic.
Descriptors (primary) France; toxicology; phthalates
Descriptors (secondary) embryotoxic effects; benzyl butyl phthalate; antifertility effects; children; bis(ethylhexyl) phthalate; dioctyl phthalate; diisodecyl phthalate; polyvinyl chloride; dibutyl phthalate; liver cancer; animal experiments; expectant mothers; encyclopaedia; data sheet; criteria document; plasticizers; literature survey
Document type B - Chemical safety information sheets
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Esters and salts
Genetic factors in reaction to exposures