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CISDOC database

Document ID (ISN)104013
CIS number 05-360
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2004
Convention or series no.
Author(s) Luderer U., Bushley A., Stover B.D., Bremner W.J., Faustman E.M., Takaro T.K., Checkoway H., Brodkin C.A.
Title Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
Bibliographic information Dec. 2004, Vol.46, No.6, p.614-626. Illus. 49 ref.
Abstract To assess fertility and reproductive endocrine function in solvent-exposed men, this study investigated time-to-pregnancy of in a cohort of painters and millwrights compared to a reference group of carpenters. Detailed data on occupational exposure, medical history and time-to-pregnancy were obtained by telephone interview. Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. FSH concentrations increased significantly with increasing exposures to all solvents and to chlorinated solvents. There were no significant associations of solvent exposures with LH or testosterone levels. LH, FSH, and testosterone concentrations also did not differ by job title. Time-to-pregnancy was non-significantly longer in the painters and millwrights than the carpenters. There was no significant association between time-to-pregnancy and any of the exposures. The significant associations between FSH levels and solvent exposures suggest the potential for adverse effects of solvent exposures on reproductive function in men.
Descriptors (primary) antifertility effects; construction work; solvents; male workers
Descriptors (secondary) USA; hormones; testosterone; painting; dose-response relationship; carpentry; case-control study; immunology; carpet laying
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Construction industry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects