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Document ID (ISN)103978
CIS number 05-8
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2004
Convention or series no. Fascicule 16541 A 10, 4-2004
Author(s) Maître A., Perdrix A.
Title Isocyanates
Original title Isocyanates [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 4th Quarter 2004, No.145, 5p. 64 ref.
Abstract Isocyanates are characterized by the presence of one or several highly-reactive functional groups, providing them with exceptional industrial properties. This high reactivity also explains why they represent the most important chemical cause of occupational asthma in industrialized countries, and particularly in France. The severity of the pathologies is related to the nature of the induced asthma and bronchiolitis that follow acute exposures. However, there is still a lack of understanding of both the complex physiopathological mechanisms and the mutagenic effects. The requirement for strictly-controlled technical prevention measures, particularly in spray painting, is causing users to consider substitution products.
Descriptors (primary) France; asthma; toxicology; isocyanates
Descriptors (secondary) mutagenic effects; data sheet; carcinogens; polyurethanes; compensation of occupational diseases; extrinsic allergic alveolitis; prognosis; bronchiolitis; spray booths; diagnosis; limitation of exposure; hazard evaluation; substitution; short-term exposure; medical supervision; encyclopaedia; literature survey
Document type B - Chemical safety information sheets
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Genetic factors in reaction to exposures