|Document ID (ISN)||103978|
|ISSN - Serial title
||1877-7856 - Encyclopédie médico-chirurgicale
|Convention or series no.
||Fascicule 16541 A 10, 4-2004
||Maître A., Perdrix A.
||Isocyanates [in French]|
||Toxicologie-Pathologie professionnelle, 4th Quarter 2004, No.145, 5p. 64 ref.
||Isocyanates are characterized by the presence of one or several highly-reactive functional groups, providing them with exceptional industrial properties. This high reactivity also explains why they represent the most important chemical cause of occupational asthma in industrialized countries, and particularly in France. The severity of the pathologies is related to the nature of the induced asthma and bronchiolitis that follow acute exposures. However, there is still a lack of understanding of both the complex physiopathological mechanisms and the mutagenic effects. The requirement for strictly-controlled technical prevention measures, particularly in spray painting, is causing users to consider substitution products.
||France; asthma; toxicology; isocyanates
||mutagenic effects; data sheet; carcinogens; polyurethanes; compensation of occupational diseases; extrinsic allergic alveolitis; prognosis; bronchiolitis; spray booths; diagnosis; limitation of exposure; hazard evaluation; substitution; short-term exposure; medical supervision; encyclopaedia; literature survey
||B - Chemical safety information sheets
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)
Genetic factors in reaction to exposures