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CISDOC database

Document ID (ISN)103924
CIS number 05-172
Year 2005
Convention or series no. ECETOC Technical Report No.95
Title The toxicology of glycol ethers and its relevance to man
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, 4th ed., Feb. 2005. 202p. Illus. Approx. 1000 ref. Price: EUR 125.00. Profiles of 44 substances are provided on a companion CD-ROM (included).
Abstract Glycol mono-ethers are liquids that combine the solubility characteristics of ethers and alcohols since both functional groups are present. As a result, they are widely used in solvent applications, including formulations such as paints, inks and cleaning fluids. Non-solvent applications include anti-icing agents in jet fuel, hydraulic system fluids and chemical intermediates. Glycol ethers have a high potential to penetrate the skin (as a liquid or vapour) and this represents the dominant potential route of exposure. The majority of glycol ethers are of low acute toxicity; the main effect seen in laboratory animals at high doses is narcosis, typical of many solvents. Some glycol ethers are eye irritants. Numerous studies with glycol ethers show that they do not exhibit genotoxic activity. Glycol ether exposure has been associated with anaemia, leukaemia, granulocytopenia, increased risk of abortion or reduced sperm count in painters, but these effects could be confounded by simultaneous exposure to other chemicals.
Descriptors (primary) toxicology; glycol ethers
Descriptors (secondary) toxic effects; antifertility effects; leukaemia; eye irritation; report; anaemia; criteria document; solvents; abortion; animal experiments; narcotic effects; CD-ROM; glossary; skin absorption
Document type E - Books, reports, proceedings
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Glycol ethers
Genetic factors in reaction to exposures