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CISDOC database

Document ID (ISN)103913
CIS number 05-67
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Meijer E., Grobbee D.E., Heederik D.
Title A strategy for health surveillance in laboratory animal workers exposed to high molecular weight allergens
Bibliographic information Oct. 2004, Vol.61, No.10, p.831-837. Illus. 24 ref.
Abstract The purpose of this study was to develop a model for the efficient detection and prediction of occupational allergic diseases. Data from 351 laboratory animal workers participating in an ongoing cohort study were used to develop diagnostic and prognostic models. The models were developed from questionnaire items and workplace concentration measurements to find factors for the estimation of the probability of sensitisation to allergens. The accuracy of the models was evaluated by statistical methods and by comparison of the predicted and observed prevalence. A diagnostic rule containing five questionnaire items allowed the identification of workers with a high risk of sensitisation. These workers showed high rates of work related asthma, allergic symptoms, doctor's visits and absenteeism. A prognostic rule based on four questionnaire items predicted workers at high risk of near future sensitisation.
Descriptors (primary) allergens; laboratory work; experimental animals; sensitization; risk factors; medical supervision; allergies
Descriptors (secondary) symptoms; asthma; diagnosis; questionnaire survey; frequency rates; determination in air; prediction; description of technique; statistical evaluation
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Medicine, hygiene and first aid
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Animal hazards